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Pandora's Lab: Seven Stories of Science Gone Wrong, by Paul A. Offit
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Some brilliant ideas in science led to disaster. Dr. Offit explains these sins of science and uses case studies to explain how to separate good science from bad in today's most controversial creations.
What happens when ideas presented as science lead us in the wrong direction? History is filled with brilliant ideas that gave rise to disaster, and this book explores the most fascinating -- and significant -- missteps.
Pandora's Lab takes us from opium's heyday as the pain reliever of choice to recognition of opioids as a major cause of death in the United States; from the rise of trans fats as the golden ingredient for tastier, cheaper food to the heart disease epidemic that followed; and from the cries to ban DDT for the sake of the environment to an epidemic-level rise in world malaria.
These are today's sins of science -- as deplorable as mistaken ideas from the past such as advocating racial purity or using lobotomies as a cure for mental illness. These unwitting errors add up to seven lessons both cautionary and profound, explained by renowned author and speaker Paul A. Offit. Offit uses these lessons to investigate how we can separate good science from bad, using as case studies some of today's most controversial creations: e-cigarettes, GMOs, and drug treatments for ADHD.
For every ''Aha!'' moment that should have been an ''Oh no,'' this book is an engrossing account of how science has been misused disastrously -- and how we can learn to use its power for good.
- Sales Rank: #531309 in Books
- Published on: 2017-04-04
- Formats: Audiobook, CD
- Original language: English
- Number of items: 8
- Dimensions: 5.50" h x .90" w x 5.40" l,
- Running time: 34200 seconds
- Binding: Audio CD
Review
"A fascinating and sometimes shocking look at how science can sometimes lead to disaster." —Booklist
"In warning the public of pseudoscientific danger, Offit urges the public to examine available data; beware of quick fixes, fads, and charismatic health gurus; and understand that every advance comes at a price." —Publishers Weekly
"Another rousing, pull-no-punches piece from a physician set on educating the public about the fallibility of scientists." —Kirkus Reviews
About the Author
Paul A. Offit is an author and a pediatrician specializing in infectious diseases and an expert on vaccines, immunology, and virology. He is the co-inventor of a rotavirus vaccine that has been credited with saving hundreds of lives every day. He is the Maurice R. Hilleman Professor of Vaccinology, professor of pediatrics at the Perelman School of Medicine at the University of Pennsylvania, chief of the Division of Infectious Diseases, and the director of the Vaccine Education Center at the Children's Hospital of Philadelphia. He has been a member of the Centers for Disease Control and Prevention's advisory committee on immunization.
Most helpful customer reviews
12 of 12 people found the following review helpful.
It’s not so much the science as it is a failure to critically examine the data
By Dennis Littrell
The seven stories are about:
1. Opium and opioids (“God’s Own Medicine”)
2. Oleomargarine and trans fats (“The Great Margarine Mistake”)
3. Nitrogen fertilizers and ammonium nitrate. (“Blood from Air”)
4. Eugenics (“America’s Master Race”)
5. Lobotomies (“Turning the Mind Inside Out”)
6. Rachel Carson and DDT (“The Mosquito Liberation Front”)
7. Linus Pauling and vitamin C; Peter Duesberg and AIDs; Luc Montagnier and the antibiotic “cure” for autism (“Nobel Prize Disease”)
Additionally there is an eighth chapter entitled “Learning from the Past” which is about the MMR vaccine and autism, e-cigarettes, Bisphenol A, cancer screening, and GMOs.
One of the themes in the book is the hubris of some very famous scientists who won Nobel prizes and then went on to do and/or promote some very bad science mainly because they could not admit they were wrong. But the real villain in these pages is not the science itself; it is instead the failure of people in the political arena, in the media and even in the medical and scientific journals to weigh the evidence properly thereby lending support to the bad science. Dr. Offit indicts the Environmental Protection Agency (p. 188); Time Magazine, Newsweek, the New York Times (p. 145); the Journal of the American Medical Association, the American Journal of Public Health, the New England Journal of Medicine (p. 124) and others (see page 226). Naturally these mistakes from prestigious organizations are reflective of earlier more ignorant times. Today most are much more thorough before passing judgement. However Offit warns near the end of the book that new mistakes by currently prestigious institutions will be made.
Offit, who is a doctor of medicine and a professor of pediatrics at the University of Pennsylvania as well as the author of more than 160 papers in medical and scientific journals, writes in a clear and readable style that is packed with concrete detail and facts, especially historical facts, some of which are appalling and horrific.
Here are some tidbits reflective of Offit’s engaging style:
“Francis Galton, Charles Davenport, Harry Laughlin, Madison Grant, and Adolf Hitler all shared several features: All were, by their definition, Nordic; all believed that Nordics should procreate freely while non-Nordics should be prevented from procreating; and all were childless.” (p. 122)
Today’s view of lobotomies includes the comical: the “Frontal Lobotomy” is a drink made with amaretto, Chambord and pineapple juice; a joke, “I’d rather have a bottle in front of me than a frontal lobotomy” (from Tom Waits); and a T-shirt with a picture of George W. Bush and the words, “Ask me about my lobotomy.”
In regard to Rachel Carson and her imagined Eden-like world before pesticides, Offit quotes William Cronin: “It is not hard to reach the conclusion that the only way human beings can hope to live naturally on earth is to follow the hunter-gatherers back into a wilderness Eden and abandon virtually everything that civilization has given us.” (p. 186)
Writing about Linus Pauling and other august scientists who couldn’t bring themselves to admit they were wrong, Offit offers: “When anybody contradicted Einstein, he thought it over, and if he found he was wrong, he was delighted, because he felt he had escaped from an error.” (p. 197-198)
The essence of Offit’s argument in this book is this quote from page 212: “…all scientists—no matter how accomplished or well known—should have unassailable data to support their claims, not just a compelling personality, an impressive shelf of awards, or a poetic writing style.”
--Dennis Littrell, author of “Hard Science and the Unknowable”
2 of 2 people found the following review helpful.
The misuse of science
By Reflective reader
Author explores 7 areas where scientific evidence was ignored or misrepresented. The most eye-opening chapter was "America's Master Race" where he discusses the eugenics philosophy that swept America long before Germany. Dr. Offit also tackles distortions over the "heart healthy" diet, the over-simplifications of Rachel Carson and DDT and the inexplicable promotion of Vitamin C by the brilliant scientist - Dr. Linus Pauling. Overall, the author used just enough detail to be convincing while also avoiding technical terminology.
2 of 2 people found the following review helpful.
Weird Science
By Painterofdefright
I enjoy stories about human achievement and failure (for example Eric Larsen's books) so this book was very appealing to me. Ice-pick lobotomies: brrrrrr! Unfortunately, some of the associations seem as sketchy as the bad science the author decries, for example drawing parallels between Nazi eugenic programs and Trump's rants about illegal immigrants. A better, more thorough, examination of nitrogen fertilizer is in The Alchemy of Air by Thomas Hager which I strongly recommend.
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